Abstrakt

Synthesis of certain quinoxaline derivatives of expected antiinflammatory and analgesic activities

Mohamed A.Shaaban, Samiha M.Roshdy, Mohamed A.Abd El-Gawad,Wael A.Fadaly, Gehan M.Kamel

This study involves a survey covering the synthesis, reaction and biological values of some quinoxaline derivatives. Combination of quinoxaline nucleus with certain pharmacologically active compounds (antheranilic, 4- amino benzoic, salicylic, 4-amino salicylic, 5-amino salicylic acids, 2-amino phenol and 4-aminophenol)[1] whichwere known to have anti-inflammatory and analgesic activities was the aim of this study to give a novel target compounds expected to have anti-inflammatory and analgesic activities. This was accomplished during the coarse of this thesis via three schemes each comprises the incorporation of quinoxaline nucleus with certain pharmacologically active nuclei knowing to have anti-inflammatory and analgesic activities.