Abstrakt

Synthesis, Antimicrobial and Antifungal Study of 2-(5–Aryl-4,5–Dihydro-1-Substituted-Pyrazol-3-yl)-Substituted Naphthalene-1-ol

B. P. Khobragade and P. T. Kosankar

The present studies are a part of the continuing interest on the synthesis of new dihydropyrazole derivatives. dihydropyrazole derivatives shows anti-inflammatory and analgesics properties. In view of various pharmological and biological activities of dihydropyrazole derivatives it was proposed to synthesize and microbial screening of titled dihydropyrazole derivatives. The titled dihydropyrazole derivatives were obtained by treating 1-(substituted-1-hydroxynaphthalen-2-yl)-3-aryl-prop-2-en-1-one with semicarbazide in DMF solvent. The synthesized compounds are characterized by elemental analysis, 1H NMR, IR spectroscopy. Newly synthesized compound shows an excellent antimicrobial and antifungal activities