Abstrakt

Synthesis and pharmacological activities of some new 1-substituted-3,5-dimethyl-4-[(substituted phenyl) diazenyl] pyrazoles

Sabir Hussain, Deepika Kaushik

Several-1-carbothioamide-3,5-dimethyl-4-[(substituted phenyl) diazenyl] pyrazoles (2a-d), 1-(pyridine-4-ylcarbonyl)-3,5-dimethyl-4-[(substituted phenyl) diazenyl] pyrazoles (3a-d), were synthesized. The structures of the newly synthesized compounds were supported by IR, 1H NMR and Mass spectral data. These compoundswere investigated for their, anti-inflammatory, analgesic, ulcerogenic, lipid peroxidation, antibacterial and antifungal activities. Some of the synthesized compounds showed potent anti-inflammatory activity alongwithminimal ulcerogenic effect and lipid peroxidation, compared to ibuprofen and flurbiprofen. Some of the tested compounds also showed moderate antimicrobial activity against tested bacterial and fungal strains.