Abstrakt

Synthesis and Characterization of Binuclear Complexes Derived from (E, E)-N, N''-(6-Aminopyrimidine-2, 4-Diyl) Bis-(N'-Phenylcarbimidothioic Acid; L1) and its Biological Activity

Mosaad R Mlahi and Mohsen M Mostafa

Binuclear Cu2+, Co2+, Pt4+, Pd2+ and Nd3+ complexes derived from L1 were synthesized and characterized by elemental analyses, spectral, magnetic and thermal measurements. IR, 1H-NMR and 13C-NMR spectra suggest that L1 behaves as binegative tetradentate coordinating in the thiol form via the two nitrogen of pyrimidine rings and two thiol sulfurs with losing two protons from the SH groups in all complexes except Nd3+. Tetrahedral geometry is proposed for Cu2+ and Co2+, octahedral for Pt4+ and square-planar for Pd2+ complexes. The HOMO and LUMO were estimated to confirm the geometry of L1 and the complexes. Cu2+, Co2+ and Nd3+ complexes exhibit the potent antioxidant activity upon coordination while L1, Pd2+ and Pt4+ complexes didn’t show SOD like radical scavenger activity. Finally, the cytotoxic activity assay against HePG2 cell line proved that the Nd3+ and Pd2+ complex have the highest cytotoxic activity, while L1 and other complexes showed no cytotoxic activity.