Abstrakt

Synthesis and anti-tumor activity of some novel cationic 1,3,4-thiadiazoles as DNA binders

EmanK.A.Abdelall,AbdouO.Abdelhamid

Cationic 2,3-Dihydro-1,3,4-thiadiazoles as hydrochlorides containing benzoxazole or benzothiazole moieties were designed as DNA binders and prepared from the reaction of each of 1-(2-(benzo[d]oxazol-2- yl)hydrazono)-1-chloropropan-2-one and 1-(2-(benzo[d]thiazol-2- yl)hydrazono)-1-chloropropan-2-one with each of potassium thiocyanate, thiourea and alkyl carbodithioate. All the newly synthesized compounds were confirmed by elemental analysis, spectral data, and alternative route synthesis whenever possible. Some of the newly synthesized compounds were screened toward certain cancer tumors. Docking study was operated to give a hint on their cytotoxic mechanism.