Abstrakt

Synthesis and antimicrobial activity of some new N-acetyl pyrazoline derivatives from1-(3,5-dibromo-2-hydroxy-4methyl phenyl) ethanone

Milind P.Pawar, Kartik Vyas, Nirav M.Shah, Kiran Nimavat

The newly synthesized pyrazoline derivatives exhibited moderate to good antimicrobial activity respect to standard drugs. In present investigation, we report the synthesis of N-acetyl pyrazolines fromchalcones and hydrazine hydrate using acetic acid for the reaction. These synthesized compounds were characterized on the basis of IR, 1HNMR, Mass spectroscopic data. All synthesized new N-acetyl pyrazoline derivatives were screed for antibacterial and antifungal activity against different strains as compare to standard drugs Ciprofloxacin and Griseofulvin. Compound 3c and 3d were found to be active against selected antibacterial and antifungal strains.