Abstrakt

Study of matrix metalloproteinases-3 and -9 genepolymorphisms in the prognosis of hepatocellular carcinoma in Egyptian population

Faten Zahran Mohamed, Ibrahim Mohey El-Deen, Islam Hamdy Mohamed, Nermin Raafat Abdel Fattah

This study aimed to study the relationship between the gene polymorphisms of MMP-3 and MMP-9 and the prognosis of hepatitis C virus (HCV)-related hepatocellular carcinoma (HCC) in Egyptian population. Methods: The study enrolled 180 Egyptian individuals classified into 3 groups Group I: consists of 60 apparently healthy individuals served as control Group II: consists of 60 individuals diagnosed with HCV Group III: consists of 60 individuals diagnosed with HCC. Gene polymorphisms ofMMP-3 -1, 171 5A/6A, andMMP-9 -1, 562 C/Tusing restriction fragment length polymorphism(RFLP) for amplified genomic DNA were analyzed. Results: In HCC prognosis, MMP-3 5A carriers hadhigher probability of developing HCC when compared to healthy individuals. Conclusion: MMP-3 5A allele may bea cooperative risk factor for poor prognosis in HCC patients, suggesting that further studies with larger sample size should be investigated to ensure that this gene polymorphismmight be a potentialmarker for predicting the prognosis of HCC patients in Egyptian patients.