Abstrakt

Studies on an Antimicrobial Activity of Metal (Mn, Fe, Co, Ni, and Cu) Chelates of 1, 2-Naphthoquinone 2-Oxime

V. B. JADHAV, H. P. DESHMUKH , N. R. GONEWAR, K. D. JADHAV, and R. G. SARAWADEKAR

Five transition metal chelates of the type M [NQO] 2 where M = Mn, Fe, Co, Ni, Cu: NQO = 1, 2- napthoquinone 2-oxime have been synthesized. All chelates have been characterized by modern methods such as elemental analysis, FTIR, electronic spectra and X-ray diffraction. The chelate of manganese belongs to triclinic, a = 6.3580, b = 18.9591 c = 7.5697 Å, α = 100.429, β = 74.757, γ = 66.998 and copper chelate belongs to triclinic, a = 7.5528, b = 5.8689 c = 13.6719 Å, α = 63.541, β = 92.028, γ = 103.795, scanning electron microscopy of chelates was carried out. Their particle sizes are in the range of 15-42 nm. The ligand and the metal chelates have been screened for antimicrobial activity on gram positive and gram negative bacteria and fungi and the results are compared with cisplatin as standard chemotherapy agent. Mechanism of hydrolysis of metal chelates is discussed.