Analytische Chemie: Eine indische Zeitschrift
ISSN (PRINT): 0974-7419

Abstrakt

Spectrophotometric Method for the Estimation of Glimepiride in Bulk and Pharmaceutical formulations

Y. Padmanabha Reddy, C. Sowmya, M. Santhosh Raja, K. Raghu Pavan Kumar, B. Suresh and T. Chaithanya


A simple, sensitive and resproducible spectrophotometric method for the analysis of glimepiride in pure form and in pharmaceutical formaulations has been developed. glimepiride is a synthetic oral hypoglycemic agent, which belongs to the class of sulfonylureas used in treatment of type- 2 diabetes mellitus. Glimepiride exhibited maximum absorbance at 226.0 nm with an apparent molar absorptivity of 2.94 x 106. Beer’s law was obeyed in the concentration range of 2-32 μg/mL. Results of the analysis were validated statistically and by recovery studies. This method is successfully employed for the determination of glimepiride in various pharmaceutical preparations.


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