Abstrakt

Some new thioxopyrimidinones, thiazolopyrimidinone derivatives using diary epoxypropanones as precursor as potential antimicrobial agents

Eman R.Kotb, Nabil M.Yousif, Maher A.M.El-Hashash,Mowafia A.M.Salama, Nayera A.M.Abdelwahed, Hemat S.Khalaf

3-(4-chlorophenyl)-1-(2-naphthayl)-2,3-epoxypropanone (2) reactwith thiourea and urea to give 4-(4-chlorophenyl)hexahydro-6-(2-naphthyl)-2- thioxopyrimidine-5-one (3) and 4-(4-chlorophenyl)hexahydro-6-(2- naphthyl)pyrimidine-2,5-dione (4) respectively. Reaction of (3) with each of bromoacetic acid and 2-bromopropionic acid produced thiazolo[3,2- a]pyrimidine-3,6-diones 5 and 2-methyl-thiazolo[3,2-a]pyrim- idine-3,6-dione (6) successively.Also some newderivatives (7-14) were prepared fromthe reaction of compounds (3) and (5) with different reagent. Compound (3) was glycosidated with chloroethyl methyl ether and 2-chloroethanol to afford compound (15) and (16); newly synthesized compounds were tested for their antimicrobial evaluation.Among the assayed compounds derivatives (14a), (3), (8b), (8c) and (14b) showed the highest effect compared with the other tested compounds but not more than the satandered.