Abstrakt

Selective determination of itraconazole in the presence of its oxidative degradation product

Amr M.Badawey, Nesrine T.Lamie, Abd El-Aziz B.Abd El-Aleem

Stability-indicative determination of itraconazole (in the presence of its oxidative degradation product, is investigated. The degradation product has been isolated, via oxidative-degradation, characterized and elucidated. Selective quantification of itraconazole, singly in bulk form, pharmaceutical formulations and/or in the presence of its oxidative degradation product is demonstrated. The indication of stability has been undertaken under conditions likely to be expected at normal storage conditions. Among the spectrophotometric methods adopted for quantification are second derivative (2D), first derivative of ratio spectra (1DD), Difference spectrophotometry and bivariate analysis.