Abstrakt

Quinazoline Derivatives with Potent Anti-Inflammatory and Anti-Allergic Activities

P. Mani Chandrika, A. Raghu Ram Rao, B. Narsaiah and M. Bhagawan Raju

The biosynthesis modulation of pro-inflammatory cytokines (PICs) has become an important strategy for pharmacological intervention in a variety of inflammatory and fibrotic disease states. Thus, inhibition of PICs will provide the basis for an effective choice of treatment in inflammatory disorders like rheumatoid arthritis (RA), chronic obstructive pulmonary disease (COPD), asthma, psoriasis, chronic bronchitis and cystic fibrosis. In this review, basic attention is directed towards the simple and fused substituted quinazolines with proven potencies whose quantitative data are consolidated from literature, which are possessing remarkable anti-inflammatory activity as nitric oxide synthase-II (NOSII) inhibitors, nuclear factor kappa B (NFKB) inhibitors, tumor necrosis factor-alpha (TNF-) inhibitors, interleukin-6 (IL-6) inhibitors and combined type 3 and 4 phosphodiesterase (PDE) inhibitors with both bronchodilatory and anti-inflammatory properties.