Abstrakt

Novel chalcones of 1-(4-(4-((6-((7chloroquinolin-4-yl) amino) hexyl) amino)-6 ((4-nitrophenyl) amino)-1,3,5-triazin-2-yl) amino) phenyl) ethanone for Biological Applications: Synthesis, Characterization and Antimicrobial Studies)

E Bagyaraj, K Moorthi, S Manikandan and M Aboobuckersithique

A series of biologically active chalcones are prepared using 1-(4-(4-((6-((7chloroquinolin-4-yl)amino)hexyl)amino)-6-((4-nitrophenyl)amino)-1,3,5-triazin-2-yl)amino)phenyl)ethanone and different substituted aromatic aldehyde under bio-friendly method. Prepared chalcones are characterized by IR, 1H-NMR and tested for their antimicrobial activity against a gram positive and gram negative bacteria's are using Minimum Inhibitory Concentration (MIC) method. Chlorine containing chalcones shows high antibacterial activity against tested bacteria, among the synthesized chalcones.