Abstrakt

In vivo evaluation of hair growth potential of Stachytarpheta jamaicensis ethanolic leaves extract on sprague-dawley rats

M.H.Wan Rozianoor, M.Fatin Nadia, D.Dzulsuhaimi

This study was carried out to determine the effectiveness of S.jamaicensis leaves extract as hair growth promoter on Sprague Dawley rats. The rats were divided into three groups; control group, positive control group and test group which received no treatment, 2% minoxidil, and S.jamaicensis leaves extract respectively.All of the treatments were done in 30 days. The length of the hair was measured every five days. Primary irritation test shows that there was no erythema or edema on the rats after being applied with 10% concentration of extract. Hair length with the most significant value was on rats treated with 2%minoxidil (14.58±0.02 mm) towards day 30, followed by 2%extract (14.23±0.05 mm), and control group (11.07±0.14 mm). Histologywas done every ten days to determine the anagen to telogen ratio hair phases.Anagen phase on day 30 reached 96%of rats treated with 2%minoxidil, followed by 84%with 2%extract, and control group, 83%. In conclusion, S.jamaicensis is an effective hair growth promoter as hair length treated with S.jamaicensis leaves extract showed significant difference (p value=0.05). This may be due to the presence of palmitic acid that has antiandrogenetic alopecia property.