Abstrakt

Electron impact ionization mass spectra of 1, 2, 4-triazine derivatives with antimicrobial activity

M.H.Sherif, H.Abd El-Hady

2– (Aminothiocarbonyl) -3- aryl – 5 – arylidene – 1, 2, 4-triazin – 6– ones (3a-c) were prepared via condensation of oxazolinones (2a-c) with thiosemicarbazide. 1-methyl – 3 – thioxo – 4 –aryl – 6– arylidene – triazolo – [2, 1–a] – 1, 2, 4 – triazin–7 – ones (4a –c) were obtained by refluxing compound (3) with acetic anhydride. Treatment of (3) with benzoyl chloride in acetic acid yielded the corresponding 2– (benzoylamine) thiocarbonyl–3–aryl–5 arylidene–1, 2, 4-– triazin–6–ones (5). The electron impact ionization mass spectra of compounds (3b), (4a), (4b), (5a) and (5b) showed a weak molecular ion peak and a base peak of m/z 139 resulting from a cleavage fragmentation, but the compound (3a) a base peak atm/z 138. The compounds (3c) and (5c) gave a characteristic fragmentation patternwith a very stable fragment atm/z 104, while the compound (4c) was atm/z 119.