Abstrakt

Application Of Condensation Reactions For The Estimation Of Alfuzosin Hydrochloride In Bulk Drugs And In Pharmaceutical Formulations

D.Gowri Sankar, M.Vamsi Krishna, A.K.M.Pawar

Three simple spectrophotometric methods are described for the determination of alfuzosin hydrochloride (AFZ) in bulk drugs and in pharmaceutical formulations. The methods are based on the formation of coloured condensation products with aromatic aldehydes namely p-dimethyl aminobenzaldehyde (PDAB), p-dimethyl aminocinnamaldehyde (PDAC) or vanillin (3-methoxy-4-hydroxy benzaldehyde) and exhibiting maximum absorption at 565 nm, 560 nm and 580 nm respectively. The optimum experimental parameters for the color production are selected. Beer’s law is valid with in a concentration range of 20 - 100 μg/ml for PDAB, 8.0 - 40.0 μg/ml for PDAC and 12-60 μg/ml for vanillin. The results obtained are reproducible and are statistically validated and found to be suitable for the assay of alfuzocin hydrochloride.