Abstrakt

Anovelmethod for synthesis of some new heterocyclic compounds derived from(E)-2-benzylidenecyclohexanonewith expected biological activity

Amira Atef Ghoneim

We synthesized several heterocyclic compounds from (E)-2- benzylidenecyclohexanone 1. That was reacted with pyridine-2-amino 2, and also reacted with 4- ethylthiosemicarbazide followed by cyclization with 2-bromo-1-p-tolyehanone. On the other hands, a series of phenyl quinoline derivatives were prepared by the reaction with cyanoacetamide followed by ethylchloroacetate. The fused- ring pyrazole were obtained via the reaction of compound 1 with hydrazine hydrate in ethanol and hydrazine hydrate in acetic acid. The structure of the newly synthesized compounds has been established on the basis of their analytical and spectral data. The biological activity of the prepared compounds was also described.