Abstrakt

Analgesic and anti-inflammatory activity of Adiantum venustum..

Mohammed Hussain M, Pichandy Muthuprasanna, Srinivasarao T, Malarkodi Velraj, Shanmugapandian P and Kannaiyan Suriaprabha

Adiantum venustum is a plant belongs to the family adiantaceae. The dried powdered plant material was extracted with ethanol and it showed positive test for flavonoids, alkaloids, saponins and carbohydrates. An attempt was made to correlate the analgesic and anti-inflammatory activity of the crude extract with a standard synthetic drugs - paracetamol (150mg/ kg) and Diclofenac sodium(10mg/kg). The analgesic property was evaluated by EddyÂ’s hot plate method. A good analgesic activity was seen with (100mg/kg)when comparedwith other dose levels (50mg/kg). Chronic antiinflammatory studywas evaluated by carrageen induced pawedemamethod. The result of anti-inflammatory study at two dose levels tested in rats, exhibited significant anti-inflammatory activity. The maximumpercentage inhibition of inflammationwas (71.15%) recorded with 100mg/kg of plant extract. A further decrease in dose level (50mg/kg) showed decrease in anti-inflammatory activity.